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FRIDAY, Jan. 12, 2024 (HealthDay Information) — Medication like Wegovy and Ozempic, which have turn into a wildly well-liked approach to shed weight or battle diabetes, present no hyperlink to suicidal ideas or actions, the U.S. Meals and Drug Administration stated Thursday.
“Our preliminary analysis has not discovered proof that use of those medicines causes suicidal ideas or actions,” an FDA overview launched Thursday said.
Nonetheless, the company famous officers can’t rule out that “a small threat could exist,” and it’ll proceed to look into related experiences involving this class of weight-loss medicine, generally known as GLP-1 medicines.
The FDA overview comes on the heels of a examine funded by the Nationwide Institutes of Well being that confirmed individuals taking semaglutide, the energetic ingredient in each Ozempic and Wegovy, had a decrease threat of suicidal ideas than these taking different medicine to deal with weight problems and diabetes.
In that examine, researchers tracked over 240,000 overweight individuals and greater than 1.5 million individuals with sort 2 diabetes. They appeared on the threat of suicidal ideation inside six months of beginning the medicines, in addition to at later instances.
At six months, it discovered that amongst individuals taking the drug for weight reduction, semaglutide was linked to a 73% decrease threat of first-time suicidal ideation and a 56% decrease threat of recurrent suicidal ideation. The medicine that semaglutide was in comparison with included bupropion, naltrexone, orlistat, topiramate and phentermine.
For individuals with sort 2 diabetes, the reductions have been 64% and 49%, respectively. Right here, the medicine that semaglutide was in comparison with included insulin, metformin and newer courses of medicines generally known as DPP-4 and SGLT-2 inhibitors.
Research writer Dr. Rong Xu, a professor of biomedical informatics at Case Western Reserve College College of Medication in Cleveland, advised CNN that she determined to look into the problem after European regulators opened a probe into semaglutide and experiences of suicidal ideas final summer season.
Although semaglutide was related to a decrease threat of suicidal ideation within the NIH examine, the investigators wrote in a analysis briefing that the information “don’t but justify off-label therapy” for suicidal ideas.
Each Wegovy and one other not too long ago accepted weight-loss drug generally known as Zepbound have warnings of their U.S. prescribing details about the chance of suicidal habits and ideation.
Extra data
Go to Medication.com for extra on weight-loss medicine.
SOURCE: U.S. Meals and Drug Administration, information launch, Jan. 11, 2024; Related Press; CNN
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