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THURSDAY, Oct. 5, 2023 (HealthDay Information) — Whereas HDL ldl cholesterol is taken into account the “good” form for coronary heart and mind well being, an excessive amount of or too little of it might up an individual’s threat of dementia, new analysis suggests.
“This examine is particularly informative due to the big variety of individuals and lengthy follow-up,” famous examine writer Maria Glymour, of Boston College. She mentioned her staff was in a position to “examine the hyperlinks with dementia throughout the vary of levels of cholesterol and obtain exact estimates, even for folks with levels of cholesterol which are fairly excessive or fairly low.”
Nonetheless, that may’t show that prime or low ranges of HDL ldl cholesterol truly trigger dementia, the American Academy of Neurology (AAN) cautioned in its information launch in regards to the examine.
To study extra in regards to the potential connection, researchers studied knowledge on greater than 184,000 folks from the Kaiser Permanente Northern California Well being Plan, with a median age of 70. The sufferers didn’t have dementia at first of the examine.
The individuals stuffed out a survey on their well being behaviors and had their levels of cholesterol measured throughout routine well being care visits a median of two.5 instances within the following two years.
These folks have been then adopted with their digital well being data for a median of 9 years.
Greater than 25,000 examine individuals developed dementia throughout that point.
The common HDL ldl cholesterol stage for folks within the examine was 53.7 milligrams per deciliter (mg/dL). Wholesome ranges are above 40 mg/dL for males and above 50 mg/dL for ladies.
The analysis staff divided the individuals into 5 teams based mostly on their HDL levels of cholesterol. These with the best ranges of HDL ldl cholesterol (65 mg/dL or increased) had a 15% increased price of dementia in comparison with these within the center group. However these with the bottom ranges (11 to 41 mg/dL) additionally had increased dementia charges, despite the fact that these increased charges have been decrease than their high-cholesterol friends. That they had a 7% increased price of dementia in comparison with the center group.
Researchers additionally checked out LDL, or “unhealthy,” ldl cholesterol, however discovered solely a slight affiliation with the chance of dementia.
The findings have been printed on-line Oct. 4 in Neurology, the medical journal of the American Academy of Neurology.
“The elevation in dementia threat with each excessive and low ranges of HDL ldl cholesterol was surprising, however these will increase are small, and their scientific significance is unsure,” Glymour mentioned within the AAN information launch. “In distinction, we discovered no affiliation between LDL ldl cholesterol and dementia threat within the total examine cohort. Our outcomes add to proof that HDL ldl cholesterol has equally advanced associations with dementia as with coronary heart illness and most cancers.”
Dr. Howard Weintraub, scientific director of the Middle for the Prevention of Cardiovascular Illness at NYU Langone Coronary heart in New York, mentioned the findings have been surprising.
“When folks have HDL that’s 90 or 100 mg/dL, that’s related to dementia. However not these decrease numbers, 63 mg/dL or so,” Weintraub advised NBC Information.
Extra info
The American Coronary heart Affiliation has extra on ldl cholesterol.
SOURCE: American Academy of Neurology, information launch, Oct. 4, 2023; NBC Information
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